I am surprised nobody answered you because several guys here have GF and Wives from Barranquilla. I will give you the best imfo I can having been there 3 times before. IMHO, Barranquilla is very safe compared to some other cities in Colombia. It is a city that is easy to get around in and the traffic is not too bad . The area around the centro comercial Buena Vista is a nice area and also the Parque Washington area near the Barranquilla Plaza hotel is nice, Henry's cafe I liked a lot to have a good cold beer or 3 dollar martini and watch the chicas stroll by. That is i parque washington. There is a beach club about 15 minutes outside Barranquilla that has some nice beach bars , but the beach is very rocky. I think it is called Kilimanjaro, but all the taxis know it. There is some very nice Colonial, AKA Charleston SC, architecture In Barranquilla where the old money resides. Nice to take a drive or stroll. There are some seedy, poor areas like any city in the world and best avoided, but all in all i have enjoyed my visits to Barranquilla for the city, climate(dry heat) and the chicas are some of the finest in Colombia if you like a very exotic look. They are a bit flaky I found and tend to complain about there problems alot more then some other areas, but hey, we got to take the good with the bad
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KB